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√Ę??Advantages and Limitations of utilizing Clostridium species as Probiotics-ASytematic Review√Ę??√Ę??

Having reviewed the role of Gut microbiota(GM) earlier , in Gastrointestinal Tract(GIT)homeostasis  through  the  multiple bacteria  on the role of gut microbiota(GM) in obesity   as well as  metabolic disorder liketype 2 diabetes mellitus( T2DM), non alcoholic fatty liver disease(NAFLD),role of probiotics   as well as   prebiotics in preventing obesity ,NAFLD,besides engineering  probiotics   for tackling lots of diseases besides in its role in neuropsychiatric disease(NPD) prevention along    with   maintaining intestinal homeostasis,here we have tried to go further and study the role of specific commensal bacteria like the Clostridia species(spp.). Clostridia spp.,representing the major  commensal bacilli in the intestines ,influence  plenty of  salutary actions on  this homeostasis of the intestine.Thesespp. have been documented  to ameliorate inflammation  as well as  allergic diseases successfully in view of their specific  biological actions .The cellular parts as well as  metabolites they form like butyrate,secondary  bile acids  as well as  indole propionic acids exert a probiotic action  mainly via providing energy to the intestinal epithelial  cells ,by which the give strength to the intestinal barrier along with crosstalk with the immune system(reviewed by us in detail  earlier ).Hence in turn  ,the diet  as well as   state of the physiological  body shape  a specific  pattern of Clostridia spp., in gut.In view of their biological  actions Clostridia spp., have massive  potential in the form of probiotics .Yet safety evaluation has not been conducted till now,hence some nonnegligible chances of complication following l their use .Hence here we have tried to review both advantages ,in addition to difficulties in using them as probiotics to form Clostridia spp., as innovative probiotics for animal health   as well as  animal generation.

Author(s): Kulvinder Kochar Kaur

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