Journal of Pharmacy and Pharmaceutical Research Open Access

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Abstract

A novel intracutaneous microneedle delivery system for the treatment of acute migraine

Hayley Lewis

A Novel Intracutaneous Microneedle Delivery System for zolmitriptan has been developed by Zosano. This delivery system provides: Rapid non oral delivery and pulsatile PK profile, Room temperature stable formulations, Patient friendly alternative to injection,Versatile delivery platform capable of delivering large and small molecules, and vaccines. In a recent clinical trial zolmitriptan intracutaneous microneedle delivery system was highly effective for the treatment of migraine, with statistical significance compared to placebo achieved for the two co-primary endpoints of pain freedom at 2 hours and most bothersome symptom absence at 2 hours.