Genetic abnormality is a disorder that is inherited genetically and caused by one or more problems in the genome, especially a condition that is congenital. Most genetic abnormality is quite rare and can affect one person in every several thousands or millions. Abnormalities can be as small as a single-base mutation in just one gene; they can involve the addition or subtraction of whole chromosomes. Genetic abnormalities may be hereditary. While in other genetic disorders, defects may be caused by new mutations or changes to the DNA.
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