Reach Us +44-7447-215064
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Interaction between 5-HT4 and CB1 function in the pre-limbic cortex on memory consolidation deficit in inhibitory avoidance task

17th Global Neuroscience Conference

Nargol Ahmadi-Mahmoodabadi, Mohammad Nasehi, Masoumeh Emamghoreishi and Mohammad-Reza Zarrindast

Institute for Cognitive Science Studies, Iran Shiraz University of Medical Sciences, Iran Tehran University of Medical Sciences, Iran

Posters & Accepted Abstracts: J Neurol Neurosci

DOI: 10.21767/2171-6625-C1-006


This study performed to investigate the influence of bilateral post-training intra-pre limbic (PL) microinjections of serotonergic 5-HT4 receptor agents (RS67333, as a 5-HT4 receptor agonist and RS23597-190, as a 5-HT4 receptor antagonist) upon amnesia induced by a cannabinoid CB1 receptor agonist, Arachidonylcyclopropylamide (ACPA) in rats. The step-through Inhibitory Avoidance (IA) and open filed apparatuses were used to examine the memory consolidation and locomotion behaviors, respectively. Bilateral guide-cannulae were implanted to allow intra-PL microinjections of the drugs. Also, post-training administration of the drugs was performed with the volume of 0.6 μl/rat (0.3 μl/side). Based on our findings, post-training bilateral intra-PL microinjection of ACPA (0.1 and 0.5 µg/rat) decreased, whereas RS67333 (0.5 μg/rat) increased IA memory consolidation. Meanwhile, post-training bilateral intra-PL administration of RS23597-190 (0.005, 0.01, 0.1 and 0.5 μg/rat) did not alter memory consolidation. Moreover, intra-PL micro-infusion of RS67333 (0.005 μg/rat) plus the lower (0.001 µg/rat) or the higher (0.1 µg/rat) dose of ACPA potentiated or restored the memory consolidation impairment induced by ACPA, respectively. While, post-training administration of RS23597-190 (0.5 μg/rat) plus the higher dose of ACPA (0.1 μg/rat) potentiated the ACPA response. However none of the above interventions affect locomotors activity. In conclusion, our results suggest that the PL 5-HT4

Flyer image

Abstracted/Indexed in

  • Google Scholar
  • Open J Gate
  • Genamics JournalSeek
  • The Global Impact Factor (GIF)
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Proquest Summons
  • Scientific Journal Impact Factor
  • Secret Search Engine Labs