Polymer Sciences Open Access

  • ISSN: 2471-9935
  • Journal h-index: 9
  • Journal CiteScore: 3.80
  • Journal Impact Factor: 4.55
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Reach us +32 25889658

A new class of caffeic acid-derived biopolyether from medicinal plants its synthetic basic monomeric moiety and their anticancer efficacy

4th Edition of International Conference on Polymer Science and Technology
June 04-05, 2018 London, UK

V Barbakadze

Tbilisi State Medical University, Georgia I G Kutateladze Institute of Pharmacochemistry, Georgia

Posters & Accepted Abstracts: Polym Sci

Abstract:

Within the field of pharmacologically active biopolymers the area of stable polyethers seems rather attractive. The high-molecular fractions from the several species of two genera Symphytum and Anchusa were isolated by ultrafiltration of water-soluble crude polysaccharides on the membrane filter with cut-off value of 1000 kDa. According to IR, 13C and 1H NMR, 1D NOE, 2D heteronuclear 1H/13C HSQC and 2D DOSY experiments the main structural element of these preparations was found to be a new regular polymeric molecule. The polyoxyethylene chain is the backbone of this biopolymer. 3,4-Dihydroxyphenyl and carboxyl groups are regular substituents at two carbon atoms in the chain. The repeating unit of this regular caffeic acid-derived polyether, is 3-(3,4-dihydroxyphenyl)glyceric acid residue. Thus, the structure of natural polymer under study was found to be poly[oxy-1-carboxy-2-(3,4-dihydroxyphenyl)ethylene] or poly[3(3,4-dihydroxyphenyl)glyceric acid] (PDPGA). Such caffeic acid-derived biopolymer to our knowledge has not been known and has been identified for the first time. This compound represents a new class of natural polyethers. Then the racemic
monomer and its pure enantiomers (+)-(2R,3S)-2,3-dihydroxy3-(3,4-dihydroxy-phenyl)-propionic acid [(2R,3S)-DDPPA] and (-)-(2S,3R)-2,3-dihydroxy-3-(3,4-dihydroxy-phenyl) propionic acid [(2S,3R)-DDPPA] were synthesized for the first time via sharpless asymmetric dihydroxylation of trans-caffeic acid derivatives using an osmium catalyst and (DHQ)2-PHAL and (DHQD)2-PHAL as chiral auxiliaries. PDPGA is endowed with intriguing pharmacological activities as anticomplementary, antioxidant, anti-inflammatory, burn and wound healing and anticancer properties. PDPGA and its synthetic monomer exerted anticancer activity in vitro and in vivo against androgen-dependent and -independent human prostate cancer (PCA) cells via targeting androgen receptor, cell cycle arrest and apoptosis without any toxicity, together with a strong decrease in prostate specific antigen level in plasma. However, our results showed that anticancer efficacy of PDPGA is more effective compared to its synthetic monomer. Overall, this study identifies PDPGA as a potent agent against PCA without any toxicity and supports its clinical application.

Email:v_barbakadze@hotmail.com