Dept. of Pathology and Molecular Medicine,
McMaster Immunology Research Centre (MIRC)
Michael DeGroote School of Medicine (MDCL)
1280 Main St West,
Hamilton ON, L8S 4K1,
Dr. Zahoor received his Ph.D. in 2010 from the University of Tokyo, Japan in Microbiology with an emphasis in Molecular Virology. He did his postdoctoral trainings at RIKEN, Japan, US University of the Health Sciences, Bethesda, Maryland, USA and McMaster University, Canada. His research focuses on various aspects of host virus interactions. His has utilized various state-of-the-art molecular biology techniques, gene profiling and proteomics approaches to elucidate the role of host cellular factors that play an important role in the replication of HCV, BVDV, HTLV-1, KSHV and HIV-1. He is particularly interested in the mechanisms of action of viral proteins and how they impact host mRNA transcription and signal transduction pathways to effect viral replication and pathogenesis. Currently, his work involves characterizing innate antiviral and inflammatory responses to HIV-1 infection through mucosal surfaces.
1. Signal transduction
a. NF-kB pathway and latent viral infections
b. IRF3 pathway
c. Interferon Stimulated Genes (ISGs) and their antiviral roles
d. JAK-STAT pathway
e. Ubiquitin ?Proteomsal pathway
2. Innate immune responses and viral infections
3. Viral evasion of innate immunity
4. Genomics and Proteomics
a. Identification of host cellular factors which play a role in viral replication.