Antidepressants and Male Infertility: Involvement of Spermatogonial Stem Cells Self-renewal Disruption

Ali Shalizar Jalali*

Histology and Embryology Research Laboratories, Department of Basic Sciences, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran

*Corresponding Author:
Ali Shalizar Jalali
Histology and Embryology Research Laboratories
Department of Basic Sciences
Faculty of Veterinary Medicine
Urmia University, Urmia, Iran
Tel: 00984431942593
E-mail:
a.shalizar@urmia.ac.ir

Received date: February 20, 2017; Accepted date: February 22, 2017; Published date: February 27, 2017

Citation: Jalali AS. Antidepressants and Male Infertility: Involvement of Spermatogonial Stem Cells Self-renewal Disruption. J. stem cell Bio. transplant. 2017, 1:1.

DOI: 10.21767/2575-7725.100005

Visit for more related articles at Journal of Stem Cell Biology and Transplantation

Nearly 350 million people are affected by depression world-wide and antidepressants are the most commonly used medications [1,2]. Recently, it has been reported that the percentage of Americans on antidepressant therapies had nearly doubled, increasing from 6.8% to 13% and selective serotonin reuptake inhibitors (SSRIs) are the most commonly used antidepressant [3]. In line with that, it was also found that SSRIs treatment can lead to sexual side effects in 55% of patients [4]. Moreover, experimental evidence revealed that SSRIs administration depletes testicular germinal epithelium resulting in defective spermatogenesis and reduced male fertility [5,6].

Spermatogonial stem cells (SSCs) as self-renewing adult stem cells in the testis are responsible for regulated continual spermatogenesis throughout the most of a male’s lifespan and their biological activities can be influenced by chemicals and/ or radiation induced testicular damages [7,8]. Supporting these facts, it has been shown that SSRIs are associated with SSCs self-renewal suppression in adult rats confirming the possible involvement of these compounds in male germline maintenance disruption [9].

Accordingly, since antidepressants may cause severe testiculopathy, profound considerations should be given to the drastic consequences of their increased consumption.

References

 

Select your language of interest to view the total content in your interested language

Viewing options

Flyer image

Share This Article