The third pharmacological revolution marks an important stage in the evolutionary process of drugs used by humans. In less than a century, pharmacokinetic parameters and pharmacodynamic aspects have undergone important changes, providing increasingly effective therapeutic responses and a better margin of safety regarding the use of these drugs. Nano-drugs, biosimilars and monoclonal antibodies represent this moment of change and play a relevant role in the technological leap of the pharmaceutical industry. I highlight this transition period as an important milestone in the knowledge of pharmacology, therapeutics and medical practice, represented by the highly complex technological challenges to come.
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