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Temporal Variation in Murine Kidney Toxicity to the Antituberculosis Agent (Isoniazid)

Background: Isoniazid is a drug largely used for both the treatment and prophylaxis of Tuberculosis. In this study, we investigated whether INH-induced nephrotoxicity is influenced by dosing-time.

Materials and Methods: A potentially toxic INH dose (120 mg/kg) was injected by i.p. route to different groups of animals at three different circadian times: 1, 9 and 17 hours after light onset (HALO). INH administration at 1 and 9 HALO resulted in maximum and minimum nephrotoxicity respectively. Toxicity was assessed by the significant increase in both biochemical parameters of kidney function (Urea: URE, Uric Acid: URI and Creatinine: CERT) and stress oxidative (Malondialdehyde: MDA). These results were correlated with the severe and minor renal histopathological observed at 1 and at 9 HALO respectively.

Conclusion: The optimal tolerance or least side effects were detected when INH was injected in the second part of the light-rest span (9 HALO) of mice.

Author(s): Nouha Souayed*, Zohra Haouas, Ghada Souid, Abdelfattah Zakhama and Naceur A Boughattas

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