Havale Shrikant Hanumantappa, S. Venkat Rao, K. Vamsi Krishna, A.Phani Kumar and P. Ramesh Babu
The main objective of this invention is to establish a new de-esterification procedure for an active pharmaceutical ingredient Imidapril hydrochloride, its synthesis involved a selective dealkylation process in its penultimate stage, with respect to the available literature is concern most of the hydrolysis techniques reported in dry hydrogen chloride gas in 1, 4-dioxane. Here the author innovate a new method for its hydrolysis with sulphuric acid in 1, 4-dioxane and resulting product was more stable than regular.
