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Synthesis of novel coumarin derivatives and its biological evaluations

Coumarins possess a number of biological activities like anticoagulant, antimicrobial, anti-inflammatory, analgesic, antioxidant, anticancer, antiviral, antimalarial etc. Coumarin belongs to a group as benzopyrones, which consists of a benzene ring joined to a pyrone nucleus. In the present study, the thirteen new coumarin derivatives are synthesized and characterized by IR and 1H NMR spectra. These newly formed Coumarin derivatives were screened for anti-inflammatory activity by carrageenan induced rat paw edema model and antibacterial activity against Stophylococcus aureus as well as Escherichia coli by cup plate method. The synthesized coumarin derivatives were administered orally in the dose of 10 mg/kg. Ibuprofen and amoxicillin were taken as standard for antiinflammatory and antibacterial activity respectively. The result of present investigation showed that the compounds 7, 8 & 12 showed significantly (P < 0.001) inhibition against Carrageenan induced rat paw edema, but all new compounds(1-13) significantly (P<0.001) zone of inhibition against bacterial activity as compared to control group.

Author(s): Swayam Sourav Sahoo, Smita Shukla, Subhangankar Nandy and Himanshu Bhusan Sahoo

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