C. Sharma, D. V. Kohli , Smita Sharma and A.D Sharma
New Series of Antihypertensive agents Schiff bases 4'-(6-chloro-5-nitro-2-[4-(3-substitutedphenyl- acryloylamino)-phenyl]-benzimidazole-1-ylmethyl)-biphenyl-2-carboxylic acid and Side chain in the using different aromatic aldehydes have been synthesized from substituted compounds [1-10] and tested for antihypertensive activity in induced hypertensive rats. All the compounds have been found to be less active than Losartan; their structures were assigned with elemental analysis, melting point and spectral analysis like IR, 1H NMR, 13C NMR and FAB Mass.
