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Abstract

Synthesis and antihypertensive activity of Schiff bases of 4'-(6-chloro-5-nitro- 2-[4-(3-substituted-phenyl-acryloylamino)-phenyl]-benzimidazole-1-ylmethyl)- biphenyl-2-carboxylic acids

New Series of Antihypertensive agents Schiff bases 4'-(6-chloro-5-nitro-2-[4-(3-substitutedphenyl- acryloylamino)-phenyl]-benzimidazole-1-ylmethyl)-biphenyl-2-carboxylic acid and Side chain in the using different aromatic aldehydes have been synthesized from substituted compounds [1-10] and tested for antihypertensive activity in induced hypertensive rats. All the compounds have been found to be less active than Losartan; their structures were assigned with elemental analysis, melting point and spectral analysis like IR, 1H NMR, 13C NMR and FAB Mass.


Author(s): C. Sharma, D. V. Kohli , Smita Sharma and A.D Sharma

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