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Abstract

Pulsatile Drug Delivery System of Terbutaline Sulphate; Using pH Sensitive Polymer

The present work was aimed to design & characterize an oral dosage form to release Terbutaline sulphate following a programmed time period (pulsed release system). Pulsatile release tablet comprises a drug containing core and pH sensitive polymeric coating capable of delaying drug release and providing gastric resistance .The core tablets of terbutaline sulphate were prepared for the treatment of nocturnal asthma .The core tablets were prepared by direct compression method using different disintegrating agents. The cores were coated with pH sensitive polymers (Eudragit S-100, Eudragit L- 100) at different coating levels to develop a suitable dosage form which should show minimum drug release in upper regions of gastrointestinal tract (GIT). Prepared tablets were characterized for various physical parameters such as hardness, thickness, weight variation disintegration test drug content and in-vitro drug release characteristics. All the parameters were found to be in the standard range. The dissolution of best formulation F4S3, F7S3 and F11S3 have shown the lag phase of 5 hrs at 10% coating level and almost complete drug release was achieved after 11 hrs . The kinetic study data for best formulation followed zero order kinetics. Stability study of the best formulation indicates no significant difference in release profile after a period of 3 months.


Author(s): Vaishali patil, Dr. Chandrasekhara S., Dr. Nagesh C., Praveen K & Rekha S.

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  • Chemical Abstracts Service (CAS)
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  • Genamics JournalSeek
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  • The Global Impact Factor (GIF)
  • International Society of Universal Research in Sciences
  • China National Knowledge Infrastructure (CNKI)
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