European Journal of Experimental Biology Open Access

  • ISSN: 2248-9215
  • Journal h-index: 45
  • Journal CiteScore: 34.35
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days
Reach us +32 25889658

Abstract

Production of lovastatin by Aspergillus fischeri NCIM 509 using barley bran, wheat husk, rice bran and rice husk under solid state fermentation

D. Prasanna Latha and K. P. J. Hemalatha

Production of lovastatin was carried out by Aspergillus fischeri NCIM-509 using agro-industrial residues like barley bran, wheat husk, rice bran and rice husk as solid substrates under solid state fermentation. Lovastatin is a potent hypercholesterolemic drug used for lowering blood cholesterol. In recent years, lovastatin has also been reported as a potential therapeutic agent for the treatment of various types of tumors and also play a tremendous role in the regulation of the inflammatory and immune response, coagulation process, bone marrow, neovascularization, vascular tone, and arterial pressure. Among all the substrates orange pulp had given maximum yield of lovastatin. Hence optimization of various parameters had been carried out usingorange pulp. Process parameters like Incubation time (5-days), Temperature (28oC), Moisture content (60%), Inoculum age (5 days), Inoculum volume (40% v/w),pH of the medium(6.0), carbon source (2.0% Lactose) and nitrogen source(2.0% Ammonium Sulphate) were optimized and an overall yield of 9.6 mg/gds of lovastatin was obtained on implementing all the optimized conditions.