The aim of present study was to investigate the potential of stem bark of Acacia senegal (L.) Willd for antidiabetic activity in alloxan induced diabetic albino rats. Phytochemical studies showed the presence of flavonoids in ethyl acetate extract. Antidiabetic activity of stem bark of this plant was evaluated by measuring blood glucose levels and serum biochemical parameters after dosing with ethyl acetate extract. Blood samples were collected from overnight fasted diabetic rats on 0, 5, 10 and 15 days of treatment to determine glucose levels. On day 16, blood samples were collected to estimate biochemical parameters. In diabetic rats, both the doses (200 mg/kg and 400 mg/kg) of ethyl acetate extract were found to be significantly (P<0.05) active in comparison to control and favourable changes in biochemical parameters were also observed. It can be concluded from this study that the ethyl acetate extract of stem bark of A. senegal possess significant antidiabetic activity.
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