Abstract

Plant product (R) - Roscovitine valuable inhibitor of CDKs as An anti-cancer agent

Today, cancer is a human tragedy that kills the lives of our beloved people. Cancer in which cell or group of cells display uncontrolled growth, invasion and metastasis. In normal condition, Cell division and death processes are equilibrated to keep tissues at the steady state. For some adult cell renewal is either fast i.e. epithelial, endothelial and certain white blood cells or low i.e. healthy liver cells rarely die and in the adult brain there is a slow loss of cells with little or no replacement. Cell division is a highly organized process since accurate regulation of the cell cycle is essential for normal cell growth and development. CDKs are classic Ser/Thr kinase with molecular weight of 30-40 KDa. Displaying 11 sub domains shared by cell protein kinases. Phosphorylation of serine, Threonine and tyrosine residue represents one of the most common post-translational mechanisms used by cells to regulate their enzymatic and their structural proteins. This review is carried out on natural plant product (R) – Roscovitine which shows inhibitions of CDK activity. It will help to natural product chemist for finding out other sources of (R) - Roscovitine from nature, for chemist to determine various routes of its synthesis its analogues and medicinal chemist/pharmacist to determine its effect towards other CDKs and its pharmacokinetics properties.


Author(s): Bhaveshkumar D. Dhorajiya, Jigarkumar R. Patel, Mahesh H. Malani, Bharatkumar Z. Dholakiya

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