Abstract

Pharmaceutical efficacy of sapanin extracted from artemisiapallens walls with reference to MCF-7 cell line

The use of plants in treatment of various infections, disease against pathogens in increasing interest of solvent extracts from Artemisia pallens used in folk medicine. Phytochemical screening of the leaf extract of Artemisia pallens showed the presence of alkaloid, phenols, glycosides, saponin, steroids and triterpenes. The effect of saponin were analyzed and it was observed posses highest pharmaceutical potential as antimicrobial and anticancer activity. Artemisia pallens extracts may be used to treat disease caused by these organisms such as pathogenic (Bacillus lentus, Bacillus subtilis, Escherichia coli, klebsicella pneumonia, Salmonella paratyphi and fungal strains like Aspergillus niger, Aspergillus parasiticus and Monascus purpureus has been commonly tested against extract of Artemisia pallens. The results showed that the selected organisms were susceptible to the plant extracts at concentrations of 100 µg with diameter zone of inhibition when compared with standard antibiotic disc. The extract significantly inhibited breast cancer cell MCF-7 in vitro condition the plant extract has been shown to exhibit inhibition of cell growth well known for its anticancer properties. Studies with crude extract of Artemisia pallens saponin might revealed interesting results but should be considered rather preliminary. However, it is also possible that component of the crude extract extracts interact synergistically and thus induce effects observed for pure saponins. Artemisia pallens have been a valuable source of natural products for maintaining human health. The use of plant compounds for pharmaceutical purposes has gradually increased and its properties should be investigated to safety and efficiency.


Author(s): G. Renuga

Abstract | PDF

Share This Article
Awards Nomination 17+ Million Readerbase
Google Scholar citation report
Citations : 4713

Der Pharmacia Sinica received 4713 citations as per Google Scholar report

Abstracted/Indexed in
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Directory of Research Journal Indexing (DRJI)
  • Proquest Summons
  • MIAR
  • International Committee of Medical Journal Editors (ICMJE)
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs
  • CAS (Chemical Abstracting Services)
  • University of Barcelona

View More »

Flyer image