Abstract

New spectrophotometric methods for estimation of Ethacridine lactate in pharmaceutical formulations

Ethacridine lactate is an antiseptic in solutions of 0.1%; it is also used as an agent for second trimester abortion. Upto 150ml of 0.1% solution is instilled extra amniotically using a foley catheter. Three simple and sensitive spectrophotometric methods (Method A, Method B and Method C) were developed for the estimation of Ethacridine lactate in pharmaceutical formulations. These methods are based on the oxidative coupling of Eathacridine Lactate with 2,2’-bipyridyl, Bathophenanthroline and 2,4,6-tripyridyls- triazine in the presence of Fe(III) to form coloured chromophores which can be estimated at absorption maximums of 450nm, 600 and 540 respectively.. Method A, Method B and Method C obey the beers law in the concentration range of 5-25μg/ml, 4-24 μg/ml and 6-26μg/ml respectively. The methods were validated for use in routine quality control of Ethacridine lactate in pharmaceutical formulations. Interference studies were conducted and it was found that the common excipients usually present in dosage forms do not interfere in the proposed methods. The optical characteristics, regression analysis data and precision of the methods were calculated. The accuracy of the methods was evaluated by estimating the amount of Ethacridine Lactate in previously analyzed samples to which known amounts of Ethacridine Lactate was spiked. The accuracy of the methods was also conformed by comparison of the results obtained by proposed and reference methods. The methods were validated for use in routine quality control of Ethacridine Lactate in pharmaceutical formulations


Author(s): Aziz Unnisa1 , B. Hemalatha1, N. V. Chenchu Lakshmi1 and D. Srinivasulu2

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