Tingting Gao1,2 , Chunfang Ha2 , Ping Yin3 , Qing Zhang4 , Yongchao Huang5 , Young Dai5 , Serdar E. Bulun3 and Jian-Jun Wei1,3
Leiomyoma with bizarre nuclei (LM-BN) is a rare uterine smooth muscle tumor characterized by a remarkable nuclear atypia reminiscent of its malignant counterpart leiomyosarcoma (LMS). While it presents with an overall benign clinical course, the biological nature and pathogenesis of LM-BN remains largely unknown. The controversy about the r�?ů�?�?ŽnƐ�?ŝ�? between LM-BN and benign and malignant uterine smooth muscle tumors remains unresolved. To date, the diagnosis of LM-BN relies mainly on morphological c�?�?r�?c�?�?rŝƐ�?cƐ�? and no �?ī�?c�?�?�? molecular markers have been established. Here we describe and summarize recent progress in understanding this unique tumor �?n�?�?y�? with a focus on new Įn�?ŝnŐƐ regarding molecular and genomic �?ů�?�?r�?�?ŽnƐ and the �?Ž�?�?n�?�?ů r�?ů�?�?ŽnƐ�?ŝ�? of LM-BN with LMS.
