Vajihe Ghorbanzadeh, Seid Jamal Moshtaghian, Said Habibian, Abdol Ghaffar Ebadi and Omid Bavand Vandechali
Silver nanoparticles, which have well known antibacterial properties, have been used extensively in a range of medical settings. Despite the wide spread use of nanosilver products, relatively few undertaken to determine the biological effects of nanosilver exposure. The present study investigated the effect of nanosilver on ovary secondary follicles. Nanosilver at concentrations of high-dose (10 ppm) and low-dose (1 ppm) were intraperitoneal injected into rats. The rats were sacrificed after the 30 days of inject period, and the ovaries were obtained for histopathology observation. Results show that in groups, which received nanosilver for 30 days, we observed a decrease in secondary follicles numbers. No destructive effects were seen in control group. According to this study, we can propose that administration of nanosilver to the ovary appeared to have an inhibitory effect on ovulation induction.
