Pradeep Kumar Koyi
Buccal patches of Omeprazole were prepared by solvent evaporation method using HPMC E15, Polyvinyl alcohol and Eudragit which are the hydrophilic polymers in different ratios. The prepared patches were tested for physical parameters like Thickness, Folding endurance, Uniformity of weight, swelling index and Surface pH of patches and in-vitro drug release studies. All the physical parameters were fall within the limits. The drug content was uniform in all the formulated buccal patches of Omeprazole. The results indicate uniform distribution of drug within the patches. The release of Omeprazole from the buccal patch was immediate up to 45 mins and sustained up to 24hrs.Among the six formulations, the BM3 shows maximum drug release of 89.11% in 45 mins. The optimized formulation follows zero order kinetics to release the drug from the patches.
