Estimation of serum immunoglobulin E (IgE) level is a valuable diagnostic parameter in Allergic Asthma and allergic rhinitis[1,2]. This project work was done in collaboration with Dr. K. Sivanandhan who has been doing this research work for the last 20 years and has also established that Allergic Asthma and Allergic Rhinitis are curable diseases. Immunoglobulin ‘E’ (IgE) antibody has only been found in mammals and is associated with type I hypersensitivity reaction, where Immunoglobulin E level is found to be raised in a topic individuals and in some parasitic infestation like Schistsomiasis, Plasmodium falciparum etc… Atopic individuals (people who suffer from the Ig E mediated Allergies) can have upto 10 times the normal level of Ig E in their blood. In our study we took up 61 patients for IgE estimation both before and after treatment. The patients were treated by Dr. Sivanandhan with histaglobulin and other drugs. The Patients were from urban and rural areas comprising both male and females of all age groups. Out of 61 patients, 55 patients showed reduction in IgE Level (90.2%) and 6 patients showed no reduction in IgE level (9.8%) Clinically also, those patients with reduction in IgE level showed clinical improvement and these who did not have the reduction in IgE level also showed no clinical improvement. Among 61 patients 5 Patients showed 80% reduction in IgE level. 11 Patients showed 50- 80% reduction and 30 patients showed about 15-49% of reduction and 9 patients showed with 15% reduction IgE level after treatment. Hence, it is well established that the estimation of serum IgE level is a debendable laboratory data in patients suffering from allergic Asthma and allergic rhinitis.