The effect of 3 different categories of permeation enhancers on the in vitro permeation of Lamotrigine across cellophane membrane were evaluated using vertical type Franz Diffusion Cell. This work was conducted as a permeation enhancer screening study for development of Lamotrigine Transdermal Drug Delivery System. Dimethyl Sulfoxide (DMSO) at 5% v/v and Tween 80 at 0.1% v/v gave a 6 and 7 folds enhancement in permeation values respectively. SLS and Peppermint Oil did not show any enhancement in the penetration.
