American Journal of Advanced Drug Delivery Open Access

  • ISSN: 2321-547X
  • Journal h-index: 22
  • Journal CiteScore: 9.36
  • Journal Impact Factor: 5.76
  • Average acceptance to publication time (5-7 days)
  • Average article processing time (30-45 days) Less than 5 volumes 30 days
    8 - 9 volumes 40 days
    10 and more volumes 45 days

Abstract

Effect of Multi Drug Administration on Cardiac Enzymes and Tissues

Afshan Siddiq and Rafeeq Alam Khan

In the present study individual and combinations of drugs were given to rabbits for the period of 60 days and their effects on cardiac function and myocytes were observed. Results shows that as compared to control rabbits, administration of acarbose, glibenclamide individually and GLoAt combination showed highly significant increase (p <0.005) in CK. The animals received Losartan individually showed highly significant decrease (p <0.005) in CK. Animal received Atorvastatin showed significant decrease in CK (p <0.05) while animal received MAAt combination showed significant increase in CK (p <0.05). Similarly with respect to control, animals received Metformin showed significant increase (p <0.05) in GOT level and highly significant increase (p <0.005) in animals received combination GLoAt