Reach Us +441704335730


Design, synthesis and hypoglycemic activity of novel 2-(4-((2, 4- dioxothiazolidin-5-ylidene) methyl)-2-methoxyphenoxy)-N- substituted acetamide derivatives

The work reports facile synthesis of novel 2-(4-((2, 4-dioxothiazolidin-5-ylidene) methyl)-2-methoxyphenoxy)-Nsubstituted acetamide derivatives 3(a-o), accomplished in good yields in three steps, using conventional, mild reaction conditions. The synthesized compounds were evaluated for their hypoglycemic activity in Wister albino mice animal model and histopathological studies of kidney and liver were performed to check the toxicity effects of the synthesized derivatives. All derivatives have shown significant hypoglycemic activity.

Author(s): Anna Pratima G. Nikaljea, Sagar Choudharia and Hemant Une

Abstract | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Flyer image
Abstracted/Indexed in
  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • Secret Search Engine Labs