British Journal of Research Open Access

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Abstract

Degradation Study of Meloxicam by UV Spectroscopy

Safila Naveed, Safeena Nazeer and Nimra Waheed

Objective: The aim of this study was to perform the forced degradation studies i.e. the effect of heat, UV light, acid and base on different brands of meloxicam as defined under ICH guideline Q1A (R2) by using spectrophotometer.

Methodology: The degradation studies were carried out by preparing the standard solution of 200ppm of each brand of meloxicam .The working solutions were prepared from the standard solution and by the addition of 0.1 N HCl , 0.1 N NaOH and de-ionized water in separate test tube. The detection of the effect of acid and base were performed by placing the test tubes of solution of each brand at room temperature and the effect of UV and heat were performed by leaving the test tubes of solution at 320 nm and 50.C respectively.

Result: The result of this study illustrated that when different brands of meloxicam (A, B and C) were introduced in 0.1 N NaOH (basic medium) less degradation was observed in brand A and B while significant degradation was observed in brand C . When different brands of meloxicam (A, B and C) were introduced in 0.1 N HCl (acidic medium) the two brands B and C showed significant degradation while brand A showed highly significant degradation. Whereas when the different brands (A, B and C) were exposed to Ultraviolet light (320 nm) for 30 min, all of three brands A, B and C showed significant degradation. When different brands (A, B and C) were exposed to heat (50·C), brand A, B and C showed significant degradation after different time interval (0, 10, 20, 30, 40, 50 and 60 minutes).

Conclusion: The UV spectroscopy analysis of amount of degraded product is usually preferred over other methods because of less equipment cost and economical maintenance advantage. It is easy and rapid method and can be use in routine detection in QC laboratories.