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Abstract

Correlation of Microalbuminuria with Glycated Hemoglobin, Blood Pressure and Duration of Diabetes

Objective: Correlation of Microalbuminuria with Glycated Hemoglobin, Blood Pressure and Duration of Diabetes.
Methods: A total of one hundred and twenty five subjects were included in the study, out of which hundred non-insulin dependent diabetic patients were selected from diabetic clinic, and various medical units of Jinnah Postgraduate Medical Center Karachi and twenty five non diabetic healthy subjects were included in the control group. All the selected patients were grouped on the basis of duration of diabetes and the level of microalbuminuria. Groups on the basis of duration of diabetes and Groups on the basis of level of microalbuminuria.
Results: In the present study, the Comparison of age, weight, height, body mass index and duration of diabetes of control with group A, B, C and D of patient’s changes were not significant. Mean systolic blood pressure of group C and D was significantly high (p<0.01) when compared with control subjects, while the mean arterial pressure of group D was also found significantly high (p<0.05) in group D when compared with control subjects. The fasting serum glucose and glycated hemoglobin levels of group A, B, C and D were significantly high (P<0.001) in contrast to control subjects. Systolic blood pressure of group C was significantly high (P<0.05) when compared with group A. The values of glycated hemoglobin in group B, C and D were significantly greater (P<0.01, <0.01 and <0.001, respectively) when compared to group A, whereas the values were significantly. The mean values of systolic blood pressure, diastolic blood pressure, mean arterial pressure, fasting serum glucose and glycated hemoglobin levels of control and group I, II and III. The systolic blood pressure of group III was observed significantly high (P<0.01) as compared to control subjects. The fasting serum glucose and glycated hemoglobin levels of group I, II and III were significantly high (P<0.001) in contrast to control. While systolic blood pressure and mean arterial pressure of group III (P<0.01 and <0.05, respectively) and diastolic blood pressure, mean arterial pressure and glycated hemoglobin of group II were observed significantly high (P<0.05), when compared with group.
Conclusion: Improving the glycemic control, maintaining the blood pressure and early diagnosis of the disease may reduce the risk of development and progression of microalbuminuria and ultimately end stage renal damage and mortality.


Author(s): Muhammad Yousuf Memon, Muhammad Azhar Mughal, Shahida Hassan Memon, Ali Akbar Rahu and Khemomal Karira

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