Celecoxib – encapsulated liposomes of long alkyl chain lipids: Formulation, characterization and in vitro performance

The objective of the present study was to develop liposomal drug delivery system for a hydrophobic non steroidal anti-inflammatory drug, celecoxib. The celecoxib liposomes were prepared using different long alkyl chain lipids, DPPC and DSPC. All the formulations were characterized for their vesicle size profile and drug entrapment. The influence of cholesterol on drug entrapment and release pattern was analyzed. The present work showed that liposome with less amount of cholesterol (lipid/cholesterol mole ratio of 4:1) could produce good drug entrapment as well as retention behavior. Thirty days stability study showed that drug entrapment and size profile were stable in both refrigerated and room temperature. SEM analysis confirmed that liposomal samples were spherical shaped and showed concentric lamellae. Release profile showed that it follows zero order kinetics and mechanism of drug release is of diffusion. Thus, new, reproducible liposomes of celecoxib with good stability and appreciable controlled drug release with good retention of the drug for more than a day were prepared successfully.

Author(s): M.Yasmin Begum, K.Abbulu, M.Sudhakar, Aneesa

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