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Antidiabetic and Antioxidant Activity of Rhynchosia Beddomei Baker

Objective: To screen the antidiabetic and antioxidant activity of Rhynchosia beddomei whole plant by oral glucose tolerance test, streptozotocin (STZ)-induced and dexamethasone induced diabetic rats using oral administration of methanolic extract (MERB) and ethyl acetate extract (EARB). Methods: In oral glucose tolerance test, both MERB and EARB markedly reduced the external glucose load. The extracts were given orally at doses 150 mg/kg b.w. and 300 mg/kg b.w. and were observed after 21 days in STZ induced diabetes and 11 days in dexamethasone induced diabetes. In vitro models using a-amylase and a-glucosidase inhibitory assay were also evaluated. In vitro antioxidant study of the methanolic extract (MERB) and ethyl acetate extract (EARB) was done by DPPH assay and NBT inhibition assay respectively. Results: From the preliminary phytochemical investigation Rhynchosia beddomei whole plant showed the presence of flavonoids, phenolics and steroids. The antioxidant effect of plants are often attributed to the presence of phytochemical constituents mainly phenolics, flavonoids and flavonols. MERB at 300 mg/kg b.w. was found to have significant antioxidant and antidiabetic activity. Conclusion: This study clearly shows that the extracts of Rhynchosia beddomei possess effective antioxidant and antidiabetic activity

Author(s): N.V.L. Suvarchala Reddy V, J.L. Mary, N.M. Raghavendra and C.V.S Subrahmanyam

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