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Abstract

Anticarcinogenic effects of nothapodytes nimmoniana against Dalton’s lymphoma ascites tumor model

The aim of the present study was to explore the effect of ethanolic extract of Nothapodytes Nimmoniana heartwood and barks against Dalton’s Ascitic Lymphoma (DAL) in Swiss mice. DAL cells were injected intraperitoneally 1X106 cell to the mice. Two days after cells injection the animals were treated with ethanolic extract heartwood and barks at dose of 200 mg/kg for 14 days. 5-fluorouracil (20 mg/kg) was used as reference drug. On day 11, cancer cell number, packed cell volume, decrease in tumour weight of the mice, increase in life span and haematological parameters were evaluated and compared with the same parameters in control. A significant increase in the life span and a decrease in the cancer cell number and tumour weight were noted in the tumour-induced mice after treatment with the extract. The hematological parameters were also normalized by the extract in tumour-induced mice. These observations are suggestive of the protective effect of ethanolic extract of heartwood and barks against Dalton’s Ascitic Lymphoma (DAL).


Author(s): Senthil Rajan Dharmalingam, Rajkumar Madhappan, Srinivasan Ramamurthy, Venkata Srikanth Meka, Suresh Shanmugham1 and Senthil Kumar K. L.

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