Abstract

An efficient synthesis of novel pyrimido[1,2-a]benzimidazole derivatives and evaluation of their biological activity

Synthesis of pyrimido[1,2-a]benzimidazole derivatives (4a-j) is based on the Biginelli like cyclocondensation of aromatic aldehydes and acetoacetamide derivatives with 2-amino benzimidazole containing a guanidine fragment. An efficient synthesis of novel pyrimido[1,2-a]benzimidazoles was achieved from The cyclocondensations were achieved by heating of the starting materials in dimethylformamide (DMF) under reflux conditions. Synthesized compounds were characterized by analytical and spectral (IR, 1H NMR, mass spectral and elemental analyses) data and have been screened for their antimicrobial activity


Author(s): Ranjit S. Pada, Ram N. Nandaniya and Viresh. H. Shah

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