Systemic lupus erythematosus is the multisystemic autoimmune disorder with a larger spectrum of clinical symptoms encompassing almost all organs and tissues. The disease appears to be more common rural areas than others due to negligence. Sixty-five per cent of patients with SLE have disease onset between the ages of 16 and 55 years, 20% present before age 16, and 15% after the age of 55. In this case report described about a clinical history of 26 years young women with 10 years history of lupus erythematosus. This reports comprises different stages first is preliminary stage then in second stage patient diagnose with cutaneous lupus erythematosus at age of 14-18 years. At final stage cutaneous lupus erythematosus developed into systemic lupus erythematosus. Anti-nuclear antibody test especially performed for its diagnosis and corticosteroids were used for to manage this disease. After few months treatment patient health evaluated by laboratory tests and compares these reports with initial ones. In Systemic lupus erythematosus multiple body systems affected and this cannot be easily diagnose. Malar rash and red flat patches are in its initial symptoms which lead to severe complications which may be arthritis, renal involvement, neuro-disorders and pancreatitis. For to overcome this problem we can checkup properly and well diagnosed by laboratory tests and its duty of health care officers.