Reach Us +44-1904-929220


2-Mercaptobenzimidazole Derivatives: Synthesis and Anticonvulsant Activity

Totally a series of 2-mercaptobenzimidazole derivatives (1A-1J) were synthesized by mannich reaction from 2-mercaptobenzimidazole by reaction with compounds having secondary amine and formaldehyde. The purity of the synthesized compounds was checked by melting point and TLC and their structure was established by various analytical techniques such as IR and 1HNMR spectral studies. Anticonvulsant activity was evaluated for newly synthesized 2- mercaptobenzimidazole derivatives by maximum electrical shock induced convulsion method. Most of the synthesized compounds exhibited highly significant anticonvulsant activity.

Author(s): K. Anandarajagopal, Ravi N Tiwari, K.G.Bothara, J.Anbu Jeba Sunilson, C. Dineshkumar and P. Promwichit

Abstract | PDF

Share this  Facebook  Twitter  LinkedIn  Google+
30+ Million Readerbase
Recommended Conferences
Flyer image
Abstracted/Indexed in
  • Chemical Abstracts Service (CAS)
  • Index Copernicus
  • Google Scholar
  • Genamics JournalSeek
  • China National Knowledge Infrastructure (CNKI)
  • CiteFactor
  • Electronic Journals Library
  • Directory of Research Journal Indexing (DRJI)
  • WorldCat
  • Proquest Summons
  • Publons
  • Serials Union Catalogue (SUNCAT)
  • Geneva Foundation for Medical Education and Research
  • Secret Search Engine Labs